A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopietic dysfunction

Nature Communications (2020), A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopietic dysfunction. Human Exome sequencing performed by Otogenetics links compound heterozygous variants with pediatric autoinflammatory disease, chronic recurrent multifocal osteomyelitis (CRMO) in patients.  https://www.nature.com/articles/s41467-020-16819-z.pdf