Intratumoral heterogeneity and tumor-host crosstalk alter drug sensitivity of clonal subpopulations in a pancreatic cancer model

EE Vietsch, SM Roth, JK Simmons, A Javaid, MD Park… Intratumoral heterogeneity and tumor-host crosstalk alter drug sensitivity of clonal subpopulations in a pancreatic cancer model… Exome sequencing was performed by Otogenetics (Nor- cross, GA). In short, mouse exons were captured with an Aligent V4 kit and paired-end 100 nucleotide reads were obtained from the HiSeq2000 (Illumina) with a 30X coverage …